{"id":7075,"date":"2021-10-12T16:36:53","date_gmt":"2021-10-12T16:36:53","guid":{"rendered":"https:\/\/factor-h.org\/?p=7075"},"modified":"2021-10-12T17:15:27","modified_gmt":"2021-10-12T17:15:27","slug":"selective-targeting-of-mhtt-presents-novel-therapeutic-approach-to-huntingtons-disease","status":"publish","type":"post","link":"https:\/\/factor-h.org\/es\/selective-targeting-of-mhtt-presents-novel-therapeutic-approach-to-huntingtons-disease","title":{"rendered":"La focalizaci\u00f3n selectiva de mHTT presenta un enfoque terap\u00e9utico novedoso para la enfermedad de Huntington"},"content":{"rendered":"<p>Los factores de transcripci\u00f3n de prote\u00ednas con dedos de zinc modificados se muestran prometedores en la investigaci\u00f3n de la enfermedad de Huntington al reprimir selectivamente la HTT mutante, afirma un art\u00edculo publicado por Perking Elmer el pasado jueves 7 de octubre. <\/p>\n\n\n\n<p>Perking Elmer informa que los investigadores de la Fundaci\u00f3n CHDI y Sangamo Therapeutics creen que la terapia ideal ser\u00e1 aquella que elimine por completo la expresi\u00f3n de mHTT sin interferir con la funci\u00f3n normal de HTT. En un esfuerzo por hacer precisamente eso -dice la compa\u00f1\u00eda-, \u201chan dise\u00f1ado factores de transcripci\u00f3n de prote\u00ednas con dedos de zinc (ZFP-TF) para apuntar a la repetici\u00f3n CAG patog\u00e9nica y reducir selectivamente el mHTT como estrategia terap\u00e9utica. El art\u00edculo presenta al Dr. Bryan Zeitler, cient\u00edfico principal de Sangamo Biosciences, e Ignacio Mu\u00f1oz-Sanju\u00e1n, autor principal de la Fundaci\u00f3n CHDI.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote has-text-align-center is-layout-flow wp-block-quote-is-layout-flow\"><p>La terap\u00e9utica ideal ser\u00e1 aquella que elimine por completo la expresi\u00f3n de mHTT <\/p><p>sin interferir con la funci\u00f3n HTT normal.<\/p><cite>Ignacio Mu\u00f1oz-Sanjuan<\/cite><\/blockquote>\n\n\n\n<p>Para leer el art\u00edculo completo, haga clic en <a href=\"https:\/\/resources.perkinelmer.com\/lab-solutions\/resources\/docs\/ATL-huntingtons-disease-therapeutic-research.pdf#:~:text=Selective%20Targeting%20of%20mHTTPresents%20Novel%20Therapeutic%20Approach%20to,another%20200%2C000%20at%20risk%20of%20developing%20the%20condition\" target=\"_blank\" rel=\"noreferrer noopener\">AQU\u00cd<\/a>.<\/p>\n\n\n\n<p>Fuente:<a href=\"https:\/\/www.perkinelmer.com\/libraries\/ATL-huntingtons-disease-therapeutic-research?utm_source=Twitter-PerkinElmer&amp;utm_medium=Social&amp;utm_campaign=LSC-NS-2021-GLO-DG-PaidSocial-ZZ-HDWP&amp;sfdc_id=7014V000002YrXc&amp;LS=Organic-Twitter\" target=\"_blank\" rel=\"noreferrer noopener\"> Sitio web de PerkinElmer <\/a><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>Los factores de transcripci\u00f3n de prote\u00ednas con dedos de zinc modificados se muestran prometedores en la investigaci\u00f3n de la enfermedad de Huntington al reprimir selectivamente la HTT mutante, afirma un art\u00edculo publicado por PerkingElmer el pasado jueves 7 de octubre. <\/p>","protected":false},"author":4,"featured_media":7076,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[9,29],"tags":[130,131,129,132,133],"class_list":["post-7075","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general-news","category-research","tag-chdi","tag-factor-h","tag-ignacio-munoz-sanjuan","tag-mhtt","tag-sangamo"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/factor-h.org\/es\/wp-json\/wp\/v2\/posts\/7075","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/factor-h.org\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/factor-h.org\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/factor-h.org\/es\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/factor-h.org\/es\/wp-json\/wp\/v2\/comments?post=7075"}],"version-history":[{"count":0,"href":"https:\/\/factor-h.org\/es\/wp-json\/wp\/v2\/posts\/7075\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/factor-h.org\/es\/wp-json\/wp\/v2\/media\/7076"}],"wp:attachment":[{"href":"https:\/\/factor-h.org\/es\/wp-json\/wp\/v2\/media?parent=7075"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/factor-h.org\/es\/wp-json\/wp\/v2\/categories?post=7075"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/factor-h.org\/es\/wp-json\/wp\/v2\/tags?post=7075"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}