{"id":452,"date":"2021-02-15T09:32:48","date_gmt":"2021-02-15T09:32:48","guid":{"rendered":"http:\/\/inevitablecompany.es\/?page_id=452"},"modified":"2024-06-26T17:43:45","modified_gmt":"2024-06-26T17:43:45","slug":"factor-h-the-disease","status":"publish","type":"page","link":"https:\/\/factor-h.org\/pt\/factor-h-home\/factor-h-the-disease","title":{"rendered":"Fator-H \u2013 A Doen\u00e7a"},"content":{"rendered":"\t\t
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(On the limits of human suffering)<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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the disease<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Huntington\u2019s Disease is a genetic, progressive and fatal neurodegenerative disease. It does not discriminate based on ethnicity or gender. It advances slowly, but relentlessly and affects the whole family.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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THE DISEASE. Huntington\u2019s disease (HD)<\/span> is a rare, hereditary, neurodegenerative disease that typically strikes during mid-life, between 35-55 years old, and is characterized by voluntary and involuntary motor movements, behavioral impairment and cognitive decline, leading to complete dependence, and ultimate death after a slow but unrelenting progression over two decades. Every child of an affected parent has a 50% chance of inheriting the mutated gene and therefore developing the disease. There are treatments for some symptoms of the disease (motoric and psychiatric symptoms), but no therapies slow it or prevent their ultimate demise.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Personality & mood changes... <\/h5>
Early signs and symptoms can include irritability,\u202f depression, lack of motivation, poor coordination, lack of focus, and trouble learning new information or making decisions. These signs can appear years before motor alterations. At times, personality changes are noticed by family members.\n\n<\/div>\t<\/div>\n\t\t\t
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As the disease progresses...<\/h5>
Involuntary movements will make affected individuals have trouble walking, speaking, and swallowing. The movements can be very severe and impact their quality of life. Individuals will experience more mental changes and a decline in their thinking and reasoning abilities, leading to loss of employment.<\/div>\t<\/div>\n\t\t\t
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Fatal outcome<\/h5>
Individuals with the adult-onset form of Huntington\u2019s Disease usually live about 15 to 20 years after signs and symptoms begin. Individuals become completely dependent for care, as they experience an inability to stand, speak or eat by themselves and lose body weight. A fatal outcome will inevitably arrive if she or he lives long enough. <\/div>\t<\/div>\n\t\t\t
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The Gene<\/div>
Latin America holds a special place in the scientific history of HD. In 1993 an international effort first identified the mutations causing Huntington\u2019s disease in the large number of related, affected people living in the Maracaibo region of Venezuela. <\/div>KNOW MORE<\/a><\/div><\/div><\/div>
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Research<\/div>
Because of the discovery of the gene that causes HD, today we have advanced several therapeutic programs to clinical trials targeting the mutant gene. Factor-H founders are scientists and clinicians leading these efforts, and hope to bring new therapies to affected communities everywhere.<\/div>KNOW MORE<\/a><\/div><\/div><\/div>
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Latin America<\/div>
The largest clusters of HD families reside in Latin America. Beyond the communities around Lake Maracaibo in Venezuela, other large vulnerable communities have been identified in the Caribbean Coast of Colombia, in Ca\u00f1ete, Peru, and also in Brazil, where most affected families live in conditions of extreme vulnerability.<\/div>
KNOW MORE<\/div><\/div><\/a><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t
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\n\t\t\t\t\tInformaci\u00f3n y Gu\u00edas en<\/span>\n\t\t\t\t\n\t\t\t\t\tespa\u00f1ol<\/span>\n\t\t\t\t<\/span>\n\t\t\t\t<\/h3>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Preguntas y Respuestas...<\/div>
Car\u00e1cter\u00edsticas, S\u00edntomas, Gen\u00e9tica, Herencia, Diagn\u00f3stico, Tener Descencencia, Tratamientos, Vida Cotidiana en la EH, Ayuda Para Las Personas Afectadas.<\/div>ABRIR GU\u00cdA<\/a><\/div><\/div><\/div>
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Enfermos EH: Una Gu\u00eda<\/div>
Elaborada por la Asociaci\u00f3n Corea de Huntington Espa\u00f1a<\/div>LEER LA GU\u00cdA<\/a><\/div><\/div><\/div>
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Gu\u00eda Cl\u00ednica<\/div>
Diagn\u00f3stico y Manejo de la Enfermedad de Huntington 2016, una Gu\u00eda Cl\u00ednica Auspiciada por la Agrupaci\u00f3n Chilena de Huntington que Factor-H recomienda.<\/div>LEER LA GU\u00cdA<\/a><\/div><\/div><\/div>
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Gu\u00eda Nutricional<\/div>
La presente gu\u00eda alimentaria tiene como objetivo contribuir a obtener una alimentaci\u00f3n saludable que conlleve a alcanzar un adecuado estado nutricional de las personas afectadas por la enfermedad de Huntington, mejorar la calidad de vida y evitar complicaciones asociadas a una mala nutrici\u00f3n.<\/div>LEER LA GU\u00cdA<\/a><\/div><\/div><\/div>
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Gu\u00eda del Cuidador<\/div>
Una gu\u00eda para cuidadoras y cuidadores, que incluye el cuidado a la persona dependiente y, tambi\u00e9n, el cuidado al cuidador. <\/div>LEER EL GU\u00cdA<\/a><\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t
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\n\t\t\t\t\tHere are some<\/span>\n\t\t\t\t\n\t\t\t\t\tnumbers<\/span>\n\t\t\t\t<\/span>\n\t\t\t\t<\/h3>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Families supported by Factor-H & affiliated organizations<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Colombia<\/div>\t\t\t
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Peru<\/div>\t\t\t
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Zulia, Venezuela<\/div>\t\t\t
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More news about the disease<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\n\t\t\t\tFactor-H and Skyhawk Therapeutics collaborate to Support Responsible Communication on the Falcon-HD Clinical Trial in Latin America\t\t\t<\/a>\n\t\t<\/h3>\n\t\t\t\t
\n\t\t\t\t\t\n\t\t\tfevereiro 5, 2026\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t
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A central priority for Factor-H is ensuring that information about clinical research is shared in a way that does not create unrealistic expectations or add<\/p>\n\t\t<\/div>\n\t\t\n\t\t\n\t\t\tRead More \u00bb\t\t<\/a>\n\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\tAMT-130 Marks a Historic Moment for Huntington\u2019s\u2014Now Comes Careful Communication\t\t\t<\/a>\n\t\t<\/h3>\n\t\t\t\t
\n\t\t\t\t\t\n\t\t\tsetembro 28, 2025\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t
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On July 10, 2024, I wrote a reflection piece following the investor conference where uniQure presented the encouraging 24-month results of AMT-130, the first HTT-directed<\/p>\n\t\t<\/div>\n\t\t\n\t\t\n\t\t\tRead More \u00bb\t\t<\/a>\n\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\tState of Therapeutic Programs\t\t\t<\/a>\n\t\t<\/h3>\n\t\t\t\t
\n\t\t\t\t\t\n\t\t\tjunho 26, 2024\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t
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From a gene mutation to a lethal disease HD is caused by a single mutation in a region of the HTT gene, located at the<\/p>\n\t\t<\/div>\n\t\t\n\t\t\n\t\t\tRead More \u00bb\t\t<\/a>\n\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

(On the limits of human suffering) the disease Huntington\u2019s Disease is a genetic, progressive and fatal neurodegenerative disease. It does not discriminate based on ethnicity or gender. It advances slowly, but relentlessly and affects the whole family. THE DISEASE. Huntington\u2019s disease (HD) is a rare, hereditary, neurodegenerative disease that typically strikes during mid-life, between 35-55 years […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":333,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-452","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/factor-h.org\/pt\/wp-json\/wp\/v2\/pages\/452","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/factor-h.org\/pt\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/factor-h.org\/pt\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/factor-h.org\/pt\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/factor-h.org\/pt\/wp-json\/wp\/v2\/comments?post=452"}],"version-history":[{"count":18,"href":"https:\/\/factor-h.org\/pt\/wp-json\/wp\/v2\/pages\/452\/revisions"}],"predecessor-version":[{"id":10613,"href":"https:\/\/factor-h.org\/pt\/wp-json\/wp\/v2\/pages\/452\/revisions\/10613"}],"up":[{"embeddable":true,"href":"https:\/\/factor-h.org\/pt\/wp-json\/wp\/v2\/pages\/333"}],"wp:attachment":[{"href":"https:\/\/factor-h.org\/pt\/wp-json\/wp\/v2\/media?parent=452"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}