{"id":7075,"date":"2021-10-12T16:36:53","date_gmt":"2021-10-12T16:36:53","guid":{"rendered":"https:\/\/factor-h.org\/?p=7075"},"modified":"2021-10-12T17:15:27","modified_gmt":"2021-10-12T17:15:27","slug":"selective-targeting-of-mhtt-presents-novel-therapeutic-approach-to-huntingtons-disease","status":"publish","type":"post","link":"https:\/\/factor-h.org\/pt\/selective-targeting-of-mhtt-presents-novel-therapeutic-approach-to-huntingtons-disease","title":{"rendered":"O direcionamento seletivo do mHTT apresenta uma nova abordagem terap\u00eautica para a doen\u00e7a de Huntington"},"content":{"rendered":"<p>Os fatores de transcri\u00e7\u00e3o da prote\u00edna dedo de zinco manipulados mostram-se promissores na pesquisa da doen\u00e7a de Huntington, reprimindo seletivamente o mutante HTT, afirma um artigo publicado por Perking Elmer na \u00faltima quinta-feira, 7 de outubro. <\/p>\n\n\n\n<p>Perking Elmer informa que os pesquisadores da Funda\u00e7\u00e3o CHDI e da Sangamo Therapeutics acreditam que a terap\u00eautica ideal ser\u00e1 aquela que elimine completamente a express\u00e3o do mHTT sem interferir na fun\u00e7\u00e3o normal do HTT. Em um esfor\u00e7o para fazer exatamente isso -diz a empresa-, \u201celes projetaram fatores de transcri\u00e7\u00e3o de prote\u00edna de dedo de zinco (ZFP-TFs) para atingir a repeti\u00e7\u00e3o CAG patog\u00eanica e reduzir seletivamente o mHTT como uma estrat\u00e9gia terap\u00eautica. O artigo apresenta o Dr. Bryan Zeitler, cientista principal da Sangamo Biosciences, e Ignacio Mu\u00f1oz-Sanju\u00e1n, autor s\u00eanior da Funda\u00e7\u00e3o CHDI.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote has-text-align-center is-layout-flow wp-block-quote-is-layout-flow\"><p>A terap\u00eautica ideal ser\u00e1 aquela que elimine completamente a express\u00e3o do mHTT <\/p><p>sem interferir com a fun\u00e7\u00e3o HTT normal.<\/p><cite>Ignacio Mu\u00f1oz-San Juan<\/cite><\/blockquote>\n\n\n\n<p>Para ler o artigo completo clique <a href=\"https:\/\/resources.perkinelmer.com\/lab-solutions\/resources\/docs\/ATL-huntingtons-disease-therapeutic-research.pdf#:~:text=Selective%20Targeting%20of%20mHTTPresents%20Novel%20Therapeutic%20Approach%20to,another%20200%2C000%20at%20risk%20of%20developing%20the%20condition\" target=\"_blank\" rel=\"noreferrer noopener\">AQUI<\/a>.<\/p>\n\n\n\n<p>Fonte:<a href=\"https:\/\/www.perkinelmer.com\/libraries\/ATL-huntingtons-disease-therapeutic-research?utm_source=Twitter-PerkinElmer&amp;utm_medium=Social&amp;utm_campaign=LSC-NS-2021-GLO-DG-PaidSocial-ZZ-HDWP&amp;sfdc_id=7014V000002YrXc&amp;LS=Organic-Twitter\" target=\"_blank\" rel=\"noreferrer noopener\"> Site da PerkinElmer <\/a><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>Fatores de transcri\u00e7\u00e3o de prote\u00edna dedo de zinco projetados mostram-se promissores na pesquisa da doen\u00e7a de Huntington, reprimindo seletivamente o HTT mutante, afirma um artigo publicado pela PerkingElmer na \u00faltima quinta-feira, 7 de outubro de <\/p>","protected":false},"author":4,"featured_media":7076,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[9,29],"tags":[130,131,129,132,133],"class_list":["post-7075","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general-news","category-research","tag-chdi","tag-factor-h","tag-ignacio-munoz-sanjuan","tag-mhtt","tag-sangamo"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/factor-h.org\/pt\/wp-json\/wp\/v2\/posts\/7075","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/factor-h.org\/pt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/factor-h.org\/pt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/factor-h.org\/pt\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/factor-h.org\/pt\/wp-json\/wp\/v2\/comments?post=7075"}],"version-history":[{"count":0,"href":"https:\/\/factor-h.org\/pt\/wp-json\/wp\/v2\/posts\/7075\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/factor-h.org\/pt\/wp-json\/wp\/v2\/media\/7076"}],"wp:attachment":[{"href":"https:\/\/factor-h.org\/pt\/wp-json\/wp\/v2\/media?parent=7075"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/factor-h.org\/pt\/wp-json\/wp\/v2\/categories?post=7075"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/factor-h.org\/pt\/wp-json\/wp\/v2\/tags?post=7075"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}