In this 2021 course, Dr. Ignacio Munoz-Sanjuan, VP of translational biology at CHDI Foundation, speaks to the clinicians and movement disorder residents as part of a course about Huntington’s disease organized by EHDN and MDS. The seminar focuses on our current understanding of HTT biological aspects relevant to the development…

Revealing mHTT in real-time Huntington’s disease (HD) is caused by mutations in the gene encoding for the protein huntingtin (HTT), leading to accumulation of toxic mutant HTT (mHTT) aggregates. Development of therapies aiming to reduce mHTT is hindered by the lack of imaging methods to visualize mHTT in the living…