Intersection: Huntington and poverty in the Latin-American clusters

Intersection: Huntington and poverty in the Latin-American clusters

Huntington’s disease (HD) is a genetic, fatal, and progressive neurodegenerative disease. HD does not discriminate based on ethnicity or gender. It advances slowly, but relentlessly. The disease is caused by mutations in a single gene, called Huntingtin, and the penetrance of the mutation is 100%.  If one is born with a Huntingtin mutation, today…
State of Therapeutic Programs

State of Therapeutic Programs

From a gene mutation to a lethal disease: approaches to develop therapies to slow, delay or treat symptoms of Huntington’s disease State of current therapeutic trials in HD – data from www.clinicaltrials.gov HTT targeting gene therapies By far the major area of investment to develop effective treatments for HD is targeting the…
Un resumen de los programas activos para el silenciamiento de la Huntingtina

Un resumen de los programas activos para el silenciamiento de la Huntingtina

El presidente de Factor-H expone su primera reacción y hace un primer análisis tras la noticia de la suspensión de los estudios de Fase III de Roche con Tominerse, y expone un resumen de los programas que siguen activos. Estimados amigas y amigos, esta semana ha sido una de las…
The Dancing at The Vatican Documentary

The Dancing at The Vatican Documentary

With over 20,000 views, Dancing at the Vatican documentary has been a success, and we hope this film has inspired people. We remember with fondness the trip to the Vatican and remain thankful for the words and warmth Pope Francis delivered to the HD community. The documentary is subtitled in…
A collection of short stories about HD affected individuals from Colombia

A collection of short stories about HD affected individuals from Colombia

A BOOK OF SHORT STORIES BY TATIANA HINOJOSA FROM VALLEDUPAR Tatiana Hinojosa is a well-known writer and teacher from Valledupar, Colombia. Tatiana went to grammar school with Leyla Mieles, an associate of Factor-H in Colombia, who introduced our mission to Tatiana, who quickly became aware of the need to increase…
Letter from the President

Letter from the President

2020 was a year like no other. The global Covid-19 pandemic impacted the entire world, but it has taken a heavy toll on poor communities around the world. Most of the families we assist live in vulnerable conditions, and their access to employment and medical assistance were significantly impacted.  We reacted…
Greetings from a New Year

Greetings from a New Year

It is now 9:52pm in Los Angeles and it is officially my birthday in Spain. I was born at 8am on the 8th January of 1972 – 49 years ago today. As I write this, life is the USA is very complicated – we have had an attack on democratic…
Una pastilla para tratar la enfermedad de Huntington?

Una pastilla para tratar la enfermedad de Huntington?

Si me hubiesen preguntado hace unos años que en el 2020 empezaríamos estudios clínicos con una terapia en pastilla que trataría la causa de la enfermedad, no me lo hubiera creído. Durante mucho tiempo, desde que empecé a trabajar como científico en la fundación CHDI, he trabajado mucho en el…
Nacho speaks about Factor-H at HSG conference 2020 - Insights of the Year

Nacho speaks about Factor-H at HSG conference 2020 - Insights of the Year

On November 30th, Nacho spoke about the mission, vision, and goals of Factor-H at the 2020 conference of the Huntington Study Group (HSG), a well-known and leading clinical research organization. Nacho spoke as the Insights of the Year speaker. The conference is about 35’ long and contains some videos, followed…
Updates on the clinical studies targeting HTT by Uniqure: AMT-130

Updates on the clinical studies targeting HTT by Uniqure: AMT-130

The field of therapeutic development targeting HTT is proceeding well. In addition to the ongoing efforts by Roche and Wave with antisense drugs targeting HTT, new approaches are making their way to the clinic. Uniqure just put out a press release communicating that their clinical trial -the first of its…